The remarkable increase in the knowledge of the physiology and functions of the glands of internal secretion has not been accompanied by corresponding progress in clinical endocrinology. There are several reasons for this. One is the fact that the experimental physiologist is working with a uniform stock of animals, which are presumably identical in their inherited characteristics. The clinical endocrinologist, on the other hand, is dealing with patients of quite different origin and somatic make-up. It is well known that endocrine diseases are often found in persons who also show nonendocrine deviations from the normal; that is, changes that are usually but inappropriately termed stigmas of degeneration.1 It is therefore difficult to determine whether all of the accompanying symptoms are the result of, the cause of or merely independently coincident with the endocrine condition.
There can be mentioned at least three errors into which one might fall in attempting
WARKANY J, MITCHELL AG. RELATION OF ENDOCRINE DISTURBANCES TO CERTAIN HEREDODEGENERATIVE SYMPTOMS. Am J Dis Child. 1938;55(2):231–243. doi:10.1001/archpedi.1938.01980080002001
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