The methods employed until 1933 in the treatment of gonorrheal vaginitis1 in children were largely those recommended for the treatment of gonorrhea in adults. For many years treatment with various antiseptics and gonococcocides was in vogue. They were applied in baths, douches, instillations, suppositories and ointments. Later there was added parenteral therapy, with vaccines, filtrates, nonspecific proteins, etc. Each method had and still has its ardent adherents; but in the hands of the majority of pediatricians and gynecologists the results have been disappointing.
Recently three new methods of treatment have been advocated, each attacking the problem from a different angle and each with the claim of a previously unheard of efficiency.
1. The first method consists of treatment with estrogens or with substances which produce an acid reaction in the vagina. The two types of medicament seem to be closely related in their mode of action. Estrogens administered to
BURPEE CM, ROBINOW M, LESLIE JT. GONORRHEAL VAGINITIS IN GIRLS TREATED WITH ESTRONE (THEELIN), FEVER AND SULFANILAMIDE. Am J Dis Child. 1939;57(1):1–14. doi:10.1001/archpedi.1939.01990010010001
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