In a previous paper1 a statistical analysis was presented of data for a group of patients with rheumatic infection who had been treated in the Children's Hospital, Philadelphia, during the period from 1922 to 1932 inclusive. A further follow-up study was made in 1939 of the children whose primary manifestation of rheumatic infection had occurred during the period between 1922 and 1936. Data for all children for whom a diagnosis of rheumatic infection was made were included, irrespective of the presence or absence of clinically recognizable heart disease. Details concerning the composition of this group have been reported elsewhere.2
As a result of the survey the course of 553 children (94.8 per cent of the total group) was known for a minimum period of three years and an average period of nine and six-tenths years after the primary manifestation. The severity of the disease was greatest in the
ASH R. CARDIAC SIGNS IN RHEUMATIC INFECTION OF CHILDHOOD. Am J Dis Child. 1942;63(1):1–14. doi:10.1001/archpedi.1942.02010010002001
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