Physicians have been accustomed to thinking that once a person has a positive reaction to tuberculin he will remain a reactor for the rest of his life. However, recently a succession of patients who had Ghon tubercles in the parenchyma of the lungs and calcified hilar nodes reacted negatively to both the first and the second concentrations of purified protein derivative. Inasmuch as a positive reaction to tuberculin is believed to indicate a sensitivity produced by living tubercle bacilli in the tissues, it would seem that if the reaction became negative on repeated tests this result would indicate that living bacteria no longer existed in the tissues, or, at least, that the tubercle bacilli were so completely walled off that none of the antigen was available to induce the formation of antibodies. Furthermore, this observation emphasized the fact that as an increasing number of persons receive only minimal infections with
NORVAL MA. TUBERCULIN REACTION IN CHILDREN WITH A GHON COMPLEX: REVIEW OF ONE HUNDRED AND TWELVE CASES. Am J Dis Child. 1945;70(1):1–3. doi:10.1001/archpedi.1945.02020190008001
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