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Article
April 1946

PERIOSTEAL REACTION, FEVER AND IRRITABILITY IN YOUNG INFANTS: A New Syndrome?

Am J Dis Child. 1946;71(4):333-350. doi:10.1001/archpedi.1946.02020270003001
Abstract

THE following case reports and comment are presented to call attention to a possible new syndrome with the hope that further observations and interest will clarify the present uncertainty of its nature.

REPORT OF CASES  Case 1.—S. W., a 5 month old girl, was admitted to the University of California Hospital in April 1938. Both parents and a sibling were in good health. The patient had been born at term with a normal delivery and weighed 6 pounds 14 ounces (3,120 Gm.). She had been given feedings of evaporated milk formulas, with orange juice and cod liver oil in addition. There had been no previous illnesses, but she was said to have fallen from her crib at 2 months of age.Six weeks prior to admission to this hospital she became extremely irritable, especially when handled about the face or given the bottle. She was able to take feedings once

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