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May 1946


Am J Dis Child. 1946;71(5):457-465. doi:10.1001/archpedi.1946.02020280002001

WITHINsiderable emphasis has been placed on the bone marrow as a route for parenteral administration of fluids. In this report a method for using the marrow cavity to infuse fluids is described. Some refinements in technic as well as a partial analysis of the ill effects of the method are included. Also, the case of 1 infant, in whom complicating osteomyelitis developed, is presented.

HISTORY  In 1922 Drinker1 and Doan2 independently demonstrated by perfusion experiments the adequacy of the bone marrow for infusion of fluids. In 1934 Josefson3 reported on the use of liver preparations injected into the bone marrow and advised giving fluids by this route. In 1937 Benda and his associates4 described the use of the bone marrow cavity in guinea pigs and human beings as a route for injection of drugs, bacteria, air emboli and radiopaque substances into the general circulation. Using colloidal