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July 1948

RETICULOENDOTHELIAL GRANULOMATOSIS: Report of Two Cases of Hand-Schüller-Christian Disease

Author Affiliations

From the Pathological Laboratory and Paediatric Service of the Hamilton General Hospital, Hamilton, Ontario, Canada.

Am J Dis Child. 1948;76(1):1-13. doi:10.1001/archpedi.1948.02030030008001

IN MOST of the reviews of the literature on Hand-Schüller-Christian disease, credit is usually given to Hand for the original description of the condition. In 1893, he reported a case which included defects in the skull, exophthalmos and polyuria.1 Because of the caseous-like quality of the lesions and their granulomatous nature, he considered them to be tuberculous. However, in an earlier report in 1865, Smith of London described a typical example of the condition.2 He considered the lesions to represent "dried up abscesses." In 1915, Schüller described 3 cases with various symptoms, in each of which were displayed defects in the membranous bones.3 He presented the cases from the roentgenologic point of view. For 1 case in which there was diabetes insipidus, he suggested a primary pituitary origin. Christian, in 1919, also suggested that the condition was due to a disturbance in pituitary function.4 After the