Dr. ZUELZER'S excellent discussion of the normal and the pathologic physiology of bone marrow provides a rational basis for applying this information to a clinical setting.
Historically, the conception of bone marrow as a functioning tissue is of relatively recent date. It was regarded as performing the purely mechanical function of filling the medullary cavity of the bones until about eighty years ago, when Neumann contended it functioned as a site of blood formation in postnatal life. Postmortem investigation of the effects of various diseases of the bone marrow soon followed. Lack of correlation and apparently conflicting findings in examination of the blood during life and changes in the bone marrow after death led to attempts to study bone marrow in living patients by means of surgical biopsy.
Originally, biopsy of the bone marrow was mainly undertaken as an alternative method of splenic puncture in the diagnosis of malaria and
PONCHER HG. DIAGNOSTIC APPLICATION OF STUDY OF BONE MARROW IN INFANTS AND IN CHILDREN. Am J Dis Child. 1948;76(3):227–238. doi:10.1001/archpedi.1948.02030030237001
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