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April 1947

POSTACIDOTIC STATE OF INFANTILE DIARRHEA: SYMPTOMS AND CHEMICAL DATAPostacidotic Hypocalcemia and Associated Decreases in Levels of Potassium, Phosphorus and Phosphatase in the Plasma

Am J Dis Child. 1947;73(4):391-441. doi:10.1001/archpedi.1947.02020390003001

THE MAIN attention of investigators of infantile diarrhea in the past has been directed toward understanding of the chemical events leading to acidosis and dehydration. From a recognition of the severity of the chemical changes, concepts and procedures for correcting the acidosis and the losses of extracellular fluid have been developed. However, despite great theoretic and practical advances the fatality from infantile diarrhea has continued to be high. To some extent this high fatality still may be accounted for by acidosis, which may recur during protracted diarrhea. Many infants, however, die without acidosis, dehydration or retention of nitrogen. To explain such deaths of infants, concepts of "toxemia" or of "irreversible" damage to the tissue have been introduced.

It is the purpose of this paper to report the chemical changes and the signs and symptoms of infants with diarrhea during acidosis and following recovery from acidosis. The data to be reported