Vaccination programs against rotavirus have the potential to dramatically improve the health of children worldwide. Two licensed rotavirus vaccines currently in use have been shown to be highly effective in reducing the burden and consequences of rotavirus-related disease.1 Recently, a third vaccine in late-stage development in India has shown positive results in a large clinical trial. Its approval would provide another option for global rotavirus vaccination efforts, one likely to be more affordable to developing nations where the vast majority of the approximately 500 000 annual deaths attributable to rotavirus occur.
Schwartz JL. Rotavirus Vaccines, Intussusception, and Risk-Benefit Assessments. JAMA Pediatr. 2013;167(12):1093–1094. doi:10.1001/jamapediatrics.2013.3771