Infantile colic is a common functional gastrointestinal disorder of early infancy characterized by long bouts of crying and hard-to-soothe behavior.1 On average, the crying peaks at 6 weeks of age and then diminishes by 12 weeks of age.2 Despite this self-resolving pattern, infantile colic has a substantial deleterious impact on society by negatively affecting parental health,3 resulting in decreased family functioning years later,4 with consultation for these issues leading to substantial health care expenditures.5 The immediate impact on the infant is unknown; they certainly do not seem happy. Ten years later, these infants with colic become children who have an 11-fold increased risk for developing recurrent abdominal pain, as well as an increased risk for allergic diseases and psychological disorders.6