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JAMA Pediatrics Clinical Challenge
March 2014

Rare Adverse Effect of Treatment With Minocycline

Author Affiliations
  • 1Department of Pediatrics, Children’s Mercy Hospital, Kansas City, Missouri
  • 2College of Letters and Science, University of California, Berkeley
  • 3Arthritis Center of Orlando, Orlando Health Central Hospital, Orlando, Florida
JAMA Pediatr. 2014;168(3):287-288. doi:10.1001/jamapediatrics.2013.3763

An 18-year-old woman presented with a 4-week history of a solitary painful bullous skin lesion over the lower right anterior tibia accompanied by generalized myalgia, polyarthalgia, joint stiffness, paraesthesia, and episodic ankle swelling. The lesion first appeared as a skin-colored papule and, within a week, developed an erythematous halo. Her medical history includes asthma and acne. To our knowledge, there is no family history of this condition. Her medications included minocycline hydrochloride (for 25 months for acne), ranitidine hydrochloride, contraceptive pills, and iron supplements.