Lorazepam is a benzodiazepine that acts as a γ-aminobutyric acid (GABA)–receptor agonist. Premature infants have been reported to experience seizurelike activity following the administration of lorazepam.1-4 We report 2 cases of full-term infants, each without evidence of neurologic disorder, who received lorazepam for sedation and subsequently exhibited a seizurelike activity that occurred shortly after administration and resolved within 1 hour.
Chess PR, D'Angio CT. Clonic Movements Following Lorazepam Administration in Full-Term Infants. Arch Pediatr Adolesc Med. 1998;152(1):98–99. doi:
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