Some cosmetics contain estrogens, representing a potential source of exogenous estrogen for children. In contrast to pharmaceutical preparations, the Food and Drug Administration (Rockville, Md) does not regulate cosmetics containing less than 10 000 IU of estrogen per ounce, only stating that the label should direct consumers to limit the amount of product used to less than 20 000 IU/mo.1,2 A therapeutic dose of oral ethinyl estradiol for hormone-replacement therapy in adults is 0.02 to 0.05 mg/d (4000-10 000 IU/d). An equivalent therapeutic transdermal estradiol dose for hormone-replacement therapy is 0.05 mg/d.
Li ST, Lozano P, Grossman DC, Graham E. Hormone-Containing Hair Product Use in Prepubertal Children. Arch Pediatr Adolesc Med. 2002;156(1):85–86. doi:10.1001/archpedi.156.1.85