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Comment & Response
November 2014

Nebulized Hypertonic Saline for Bronchiolitis

Author Affiliations
  • 1The Royal Children’s Hospital, Parkville, Victoria, Australia
JAMA Pediatr. 2014;168(11):1077-1078. doi:10.1001/jamapediatrics.2014.1698

To the Editor We read with interest the study by Wu et al1 recently published in JAMA Pediatrics, examining the effect of nebulized hypertonic saline vs normal saline administration in infants with bronchiolitis. We commend the authors for undertaking a large randomized clinical trial to complement existing evidence of the decreasing length of stay with hypertonic saline use.2-5 However, we have concerns regarding the study analysis and interpretation and believe cautious interpretation of the findings is warranted.

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