[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
The Pediatric Forum
October 2002

Reoccurrence of Culture-Positive Pertussis in an Infant Initially Treated With Azithromycin and Steroids

Arch Pediatr Adolesc Med. 2002;156(10):1057-1058. doi:

Epidemiologic studies have revealed an increase in the rate of pertussis infection despite massive vaccination.1,2 Since no curative treatment is available, antibacterial therapy with erythromycin, 40 to 50 mg/kg, 4 times per day for 2 weeks, is recommended in reducing the length of the illness and in limiting the spread of the infection.3 Newly developed macrolides with improved absorption, longer half-lives, and fewer adverse effects, combined with encouraging efficacy trials, have demonstrated the superiority of new macrolides over erythromycin in upper respiratory tract infections.4 This has led to a switch from erythromycin to the newly available macrolides for the treatment of pertussis. The superiority of short-term treatment with the newly developed macrolides over the conventional long-term erythromycin treatment has been demonstrated.5,6