To the Editor Paul and colleagues1 studied 120 infants and toddlers aged 2 to 47 months with acute cough. Infants and toddlers were randomized to pasteurized agave nectar mixed with natural grape flavoring and other bulking agents, natural grape-flavored water with caramel color (placebo), and a no treatment group.1 Significant symptom improvements were found for the agave nectar and placebo groups compared with the no treatment group, with no significant differences for any outcome between the agave nectar and placebo groups.1
Colloca L. Placebo Effects in Infants, Toddlers, and Parents. JAMA Pediatr. 2015;169(5):504–505. doi:10.1001/jamapediatrics.2014.3795
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