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Comment & Response
November 2015

Breastfeeding and Childhood Leukemia Incidence: Duplicate Data Inadvertently Included in the Meta-analysis and Consideration of Possible Confounders

Author Affiliations
  • 1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
JAMA Pediatr. 2015;169(11):1071. doi:10.1001/jamapediatrics.2015.2646

To the Editor We read with interest the recently published article by Amitay et al1 demonstrating an association of breastfeeding with protection from childhood leukemia. The authors describe some possible factors contributing to the biology underlying this protective association but highlight the need for further mechanistic investigation. We would like to bring attention to an additional potential contributor to breastfeeding-associated cancer protection, related to maternal cells acquired by the child during fetal development.