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March 2016

Examining the Evidence for Using Synbiotics to Treat or Prevent Atopic Dermatitis

Author Affiliations
  • 1Department of Allergy and Immune Disorders, Murdoch Childrens Research Institute, Parkville, Australia
  • 2Department of Paediatrics, University of Melbourne, Melbourne, Australia
  • 3Department of Allergy and Immunology, The Royal Children’s Hospital Melbourne, Parkville, Australia
  • 4Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia

Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA Pediatr. 2016;170(3):201-203. doi:10.1001/jamapediatrics.2015.4406

Allergic diseases, such as atopic dermatitis (AD), food allergy, asthma, and allergic rhinitis, and other noncommunicable diseases share a common underlying pathogenesis involving aberrant chronic inflammation that results from dysregulation of immune response patterns, which are established in early life.1 The infant intestinal microbiota plays a critical role in programming of healthy vs dysregulated immune response patterns and is shaped by microbial exposures and diet in the pregnant mother and during the infant’s first years.2

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