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June 6, 2016

Provocation Challenges to Evaluate Amoxicillin Allergy in Children

Author Affiliations
  • 1Division of Allergy, Asthma, and Immunology, Scripps Clinic, San Diego, California
JAMA Pediatr. 2016;170(6):e160282. doi:10.1001/jamapediatrics.2016.0282

Although β-lactam antibiotics are the most common cause of drug allergy, most patients who are labeled as being allergic to penicillin are not, either because they were never sensitized or because they have lost their allergy over time.1 Although 6% of children are labeled as being allergic to penicillin, only 4% to 9% of those so labeled are currently allergic.2 It is important to identify those who are not allergic, because children mislabeled as penicillin allergic have more medical visits, receive more antibiotic prescriptions, and have longer hospitalizations with more antibiotic-related complications.3,4