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Comment & Response
July 2016

Prenatal Antidepressant Use and Risk of Autism Spectrum Disorders in Children

Author Affiliations
  • 1Department of Pharmacology, Izmir Katip Celebi University School of Medicine, Izmir, Turkey
  • 2Terafar-Izmir Katip Celebi University Teratology Information, Training and Research Center, Izmir, Turkey
JAMA Pediatr. 2016;170(7):712. doi:10.1001/jamapediatrics.2016.0727

To the Editor The register-based cohort study by Boukhris et al1 investigating the association between prenatal antidepressant use and risk of autism spectrum disorders (ASD) in the offspring was interesting. The authors reported a significant increase in risk of ASD in children whose mothers were exposed to antidepressants and selective serotonin reuptake inhibitors (SSRIs) in the second and/or third trimesters of their pregnancy. However, we believe that the study suffers from incomplete reporting and discussion of the results, which may lead to significant misinterpretations.

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