In this issue of JAMA Pediatrics, Gottlieb and colleagues1 extend the emerging body of research on screening for and addressing social determinants of health (SDH) in health care settings. This cluster-randomized clinical trial is remarkable for many reasons, including, most notably, that a relatively straightforward intervention using college students as navigators and service connectors resulted in both a reduction in social adversity and an improvement in a global measure of child health status.