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January 2, 2017

The Relevance of Anesthetic Drug–Induced Neurotoxicity

Author Affiliations
  • 1Department of Anesthesiology and Intensive Care–Pediatrics, Odense University Hospital, Odense, Denmark
  • 2Department of Clinical Research–Anesthesiology, University of Southern Denmark, Odense
  • 3Department of Anesthesia, Royal Aberdeen Children’s Hospital, Aberdeen, Scotland
  • 4Department of Anesthesia, University Children’s Hospital, Zurich, Switzerland
  • 5Faculty of Medicine, University of Zurich, Zurich, Switzerland
JAMA Pediatr. 2017;171(1):e163481. doi:10.1001/jamapediatrics.2016.3481

Preclinical studies1-3 in young animals have demonstrated neurodegeneration and subsequent neurocognitive impairment for virtually all clinically available general anesthetic drugs. However, comparative human studies on this issue are scarce and inconclusive.