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January 2, 2017

The Relevance of Anesthetic Drug–Induced Neurotoxicity

Author Affiliations
  • 1Department of Anesthesiology and Intensive Care–Pediatrics, Odense University Hospital, Odense, Denmark
  • 2Department of Clinical Research–Anesthesiology, University of Southern Denmark, Odense
  • 3Department of Anesthesia, Royal Aberdeen Children’s Hospital, Aberdeen, Scotland
  • 4Department of Anesthesia, University Children’s Hospital, Zurich, Switzerland
  • 5Faculty of Medicine, University of Zurich, Zurich, Switzerland
JAMA Pediatr. 2017;171(1):e163481. doi:10.1001/jamapediatrics.2016.3481

Preclinical studies13 in young animals have demonstrated neurodegeneration and subsequent neurocognitive impairment for virtually all clinically available general anesthetic drugs. However, comparative human studies on this issue are scarce and inconclusive.

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