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Comment & Response
April 2017

Acetaminophen in Pregnancy and Adverse Childhood Neurodevelopment—Reply

Author Affiliations
  • 1Medical Research Centre Integrative Epidemiology Unit, University of Bristol, Bristol, Avon, United Kingdom
  • 2School of Oral and Dental Sciences, University of Bristol, Bristol, Avon, United Kingdom
  • 3Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, United Kingdom
JAMA Pediatr. 2017;171(4):396-397. doi:10.1001/jamapediatrics.2016.5040

In Reply In response to the letters received by JAMA Pediatrics regarding our findings on acetaminophen use, we highlight that we refrained from using the term significant throughout the article because according to the American Statistical Association, “well-reasoned statistical arguments contain much more than the value of a single number and whether that number exceeds an arbitrary threshold. The ASA [American Statistical Association] statement is intended to steer research into a ‘post P <.05 era.’”1

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