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May 1, 2017

Acute Kidney Injury in Children Admitted With Diabetic Ketoacidosis: Finding the Sweet Spot of Fluid Management

Author Affiliations
  • 1Division of Nephrology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
  • 2Division of Nephrology, Children’s Hospital Colorado, Aurora
JAMA Pediatr. 2017;171(5):e170009. doi:10.1001/jamapediatrics.2017.0009

Acute kidney injury (AKI), defined as an increase in serum creatinine levels and/or a decrease in urine output, is associated with worse short-term and long-term outcomes in children and adults. Specifically, AKI has been associated with longer hospital lengths of stay, an increased risk of chronic kidney disease, and higher mortality rates.1,2 With the lack of targeted therapies to prevent AKI or decrease its associated consequences, supportive care is the mainstay of treatment and focuses on fluid and electrolyte management, nutrition, prevention of further injury through close attention to medication dosing, and, when needed, renal replacement therapy.3