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Comment & Response
June 2017

Influenza Vaccination in the First Trimester of Pregnancy and Risk of Autism Spectrum Disorder

Author Affiliations
  • 1Area of Education for Appropriateness and Evidence Based Medicine, Health Protection Agency, Milan, Italy
  • 2School of Hygiene, Public Health, and Preventive Medicine, University Milan Bicocca, Milan, Italy
  • 3Unità Locale Socio Sanitaria 20, Verona, Italy
JAMA Pediatr. 2017;171(6):601. doi:10.1001/jamapediatrics.2017.0753

To the Editor In the cohort study by Zerbo et al “Association Between Influenza Infection and Vaccination During Pregnancy and Risk of Autism Spectrum Disorder,”1 the authors found that “influenza vaccination anytime during pregnancy was not associated with ASD [autism spectrum disorder] risk,” although the adjusted hazard ratio was of borderline significance (1.10; 95% CI, 1.00-1.21).