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JAMA Pediatrics Clinical Challenge
November 2017

Infantile-Onset Fever and Urticaria

Author Affiliations
  • 1Division of Pediatric Rheumatology, Department of Pediatrics, Arkansas Children's Hospital, Little Rock
  • 2Division of Pediatric Infectious Diseases, Department of Pediatrics, Arkansas Children's Hospital, Little Rock
JAMA Pediatr. 2017;171(11):1122-1123. doi:10.1001/jamapediatrics.2017.2531

A 5-year-old white girl presented with a history of recurrent fevers and urticaria since 2 months of age. The child had fevers (maximum temperature, 40°C) that lasted 3 to 5 days. Her mother reported that the fevers resolved spontaneously but continued to recur almost every month. The fever symptoms were associated with bilateral conjunctivitis, arthralgias, and irritability. The hivelike, nonpruritic urticaria did not improve with antihistamine medication and there were no known precipitating or aggravating factors. The child did not attend day care. Family history was noncontributory and her parents denied consanguinity.

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