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Comment & Response
January 2018

Rubella Vaccine—A Tale of Appropriate Caution and Remarkable Success

Author Affiliations
  • 1Global Immunization Division, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia
  • 2Emory University School of Medicine, Emory University, Atlanta, Georgia
JAMA Pediatr. 2018;172(1):95-96. doi:10.1001/jamapediatrics.2017.4178

To the Editor Lyerly et al1 refer to historical aspects of the rubella vaccination program as “a cautionary tale about caution” with lessons pertinent to ongoing Zika vaccine research. However, the US rubella vaccination program has been a tale of appropriate caution and remarkable success in the elimination of rubella and congenital rubella syndrome.2 We concur with the authors in their assertions that safety studies in pregnant women are important and that these could have overcome the initial reluctance to give rubella vaccine to women of childbearing age (WCBA). However, further points within the article warrant comment.

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