Scientific progress requires a sustained multigenerational momentum whereby new discovery builds on previous successes and failures. To achieve this legacy, the scientific community must look past the short-term gains that can be achieved through most 3- to 5-year grant mechanisms and consider how to develop systematic approaches to efficiently integrate and train early-stage investigators (ESIs). With only 10% to 18% of career development (K) grant awardees successfully transitioning to become independently funded scientists, finding ways for effective early training is imperative.1