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Comment & Response
February 2018

Adaptation of Bone to Mechanical Strain

Author Affiliations
  • 1Department of Orthopaedic Surgery, Saitama Medical University, Moroyama, Saitama, Japan
JAMA Pediatr. 2018;172(2):196. doi:10.1001/jamapediatrics.2017.4657

To the Editor In a mixed longitudinal study of healthy children, adolescents, and young adults (n = 2014; 50.7% female and 23.8% African American), McCormack et al1 showed that peak height velocity was followed by peak acquisition of whole-body bone mineral content (BMC) and the age of peak acquisition of skeletal site-specific as well as whole-body BMC was younger in females compared with males.1 These findings are in agreement with a natural homeostatic system in the skeleton.