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Comment & Response
February 2018

Are Structural Magnetic Resonance Imaging and General Movements Assessment Sufficient for Early, Accurate Diagnosis of Cerebral Palsy?—Reply

Author Affiliations
  • 1Cerebral Palsy Alliance, School of Child and Adolescent Health, The University of Sydney, Frenchs Forest, Australia
JAMA Pediatr. 2018;172(2):199. doi:10.1001/jamapediatrics.2017.4815

In Reply We thank Parikh for his excellent points and deeply appreciate his efforts to refine advanced magnetic resonance imaging (MRI) biomarkers toward multivariable prediction models in high-income contexts.

Our clinical practice guideline1 was developed from the combined body of best-available evidence, sourced using a systematic review method, and organized by panel consensus using the GRADE framework. We did not review single articles in isolation to avoid selection and reporting bias. Furthermore, we examined multiple causal pathways to cerebral palsy, not just the preterm population as cited by Parikh, which affects the denominator value used for interpreting data.

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