To the Editor In a recent issue of JAMA Pediatrics, Ahmed et al1 showed that “within the cyanotic range, a narrow range of partial pressure of arterial oxygen (PaO2) values corresponded with a wide range of arterial oxygen saturation (Sao2) values,” as expected from the oxyhemoglobin dissociation curve.1 They also showed that Pao2 and Sao2 may trend in opposite directions in serial blood gasses in the same patient, highlighting the importance of determining which parameter should be considered the gold standard of oxygenation monitoring to accomplish proper clinical decision making. Because arterial oxygen content is predominantly determined by Sao2, Ahmed et al1 suggested that within the hypoxemic range, Sao2 is superior to Pao2 in assessing oxygenation.
Nitzan I, Mimouni FB, Hammerman C. Use of Oxyhemoglobin Saturation or Oxygen Tension—An Unsolved Question. JAMA Pediatr. 2018;172(4):390. doi:10.1001/jamapediatrics.2017.5522
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