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Comment & Response
August 2018

Prenatal Ultrasonography and Autism Spectrum Disorder

Author Affiliations
  • 1Centre for Fetal Care, Queen Charlotte’s and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, England
  • 2Institute for Reproductive and Developmental Biology, Department of Surgery and Cancer, Imperial College London, London, England
  • 3Department of Development and Regeneration, KU Leuven, Leuven, Belgium
JAMA Pediatr. 2018;172(8):786. doi:10.1001/jamapediatrics.2018.1234

To the Editor The article “Association of Prenatal Ultrasonography and Autism Spectrum Disorder”1 by Rosman et al reports “significantly greater mean depth of ultrasonographic penetration in the ASD [autism spectrum disorder] group compared with the developmental delay group in the first trimester and compared with the typical development group in the first and second trimesters. Further research is needed to determine whether other variables of ultrasound exposure also have adverse effects on the developing fetus.”1 These words, which appear in the conclusion of the abstract, do not accurately reflect the findings of this case-control study. Further, in apparent contravention of JAMA Pediatrics’ guidance for reporting clinical studies of this nature, no recruitment flowchart with participant exclusion/inclusion criteria is shown, and neither a priori hypothesis, predefined primary outcome, nor sample size calculation are included.

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