[Skip to Content]
[Skip to Content Landing]
August 2018

Common Threads in Pediatric Inflammatory Diseases: Insight Into Personalized Medicine

Author Affiliations
  • 1Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
JAMA Pediatr. 2018;172(8):721-722. doi:10.1001/jamapediatrics.2018.1169

Pediatric inflammatory diseases include a spectrum of complex interactions among host genomics, immune response, and environmental exposures. Despite this common thread, alterations in these interactions lead to different disease phenotypes and are often approached by each subspecialty in isolation. In actuality, these different diseases often share causative pathways and subsequently may have common therapeutic targets. Indeed, in this era of precision medicine, integration of the expertise among different disciplines will allow us to identify therapies that are more precise and effective. By learning from one another’s successes and failures, we can develop a personalized approach to each patient, guided by the phenotype and disease severity.