To the Editor An article by Coon et al1 includes oral rehydration solution (ORS) in the list of overtreatments, as a drug for which benefits do not exceed harms.1 Oral rehydration solution is a glucose/salt combination that exploits electrogenic solute intestinal absorption, essential to replace fluid losses during acute gastroenteritis (AGE). Oral rehydration solution was defined as the most important medical advance of the 20th century2 and as the cheapest and simplest intervention that saved more lives than any other drug.
Guarino A, Bruzzese E, Lo Vecchio A. Oral Rehydration Solution—An Essential Therapy for Childhood Gastroenteritis. JAMA Pediatr. 2018;172(10):991. doi:10.1001/jamapediatrics.2018.2622
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