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Comment & Response
October 2018

Oral Rehydration Solution—An Essential Therapy for Childhood Gastroenteritis

Author Affiliations
  • 1Section of Pediatrics, Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy
JAMA Pediatr. 2018;172(10):991. doi:10.1001/jamapediatrics.2018.2622

To the Editor An article by Coon et al1 includes oral rehydration solution (ORS) in the list of overtreatments, as a drug for which benefits do not exceed harms.1 Oral rehydration solution is a glucose/salt combination that exploits electrogenic solute intestinal absorption, essential to replace fluid losses during acute gastroenteritis (AGE). Oral rehydration solution was defined as the most important medical advance of the 20th century2 and as the cheapest and simplest intervention that saved more lives than any other drug.

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