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Research Letter
November 2018

Association of Bacteremic Sepsis With Long-term Neurocognitive Dysfunction in Pediatric Patients With Acute Lymphoblastic Leukemia

Author Affiliations
  • 1School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR
  • 2Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee
  • 3Department of Oncology, St. Jude Children’s Research Hospital, Memphis, Tennessee
  • 4Department of Epidemiology and Cancer Control, St. Jude Children’s Research Hospital, Memphis, Tennessee
JAMA Pediatr. 2018;172(11):1092-1095. doi:10.1001/jamapediatrics.2018.2500

Although long-term survival in children with acute lymphoblastic leukemia (ALL) now exceeds 90%, survivors are at risk for treatment-related neurocognitive dysfunction that can persist into adulthood.1,2 We hypothesized that bacteremic sepsis during treatment for ALL contributes to long-term neurocognitive dysfunction and tested this hypothesis in a cohort study, using a propensity score–weighted model to adjust for potential confounders.3

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