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Comment & Response
January 2019

Association of Prenatal Exposures of Polybrominated Diphenyl Ethers With Hypospadias

Author Affiliations
  • 1Imperial College London, Kensington, London
JAMA Pediatr. 2019;173(1):105-106. doi:10.1001/jamapediatrics.2018.4046

To the Editor We appreciate the work of Poon et al,1 which presented polybrominated diphenyl ethers (PBDEs) as a potentially causative factor for hypospadias. This finding is highly significant because it suggests that appropriate measures could be taken to reduce the risk of developing hypospadias, which is associated with decreased quality of life in adulthood.2 However, we identified several notable limitations in this study that could challenge the authors’ conclusions and that we feel are worth discussing.