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Comment & Response
January 2019

Association of Prenatal Exposures of Polybrominated Diphenyl Ethers With Hypospadias

Author Affiliations
  • 1Department of Pediatrics, Heng Chun Christian Hospital, Pingtung, Taiwan
  • 2Department of Pediatrics, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan
JAMA Pediatr. 2019;173(1):106. doi:10.1001/jamapediatrics.2018.4049

To the Editor We read with great interest the article by Poon et al1 showing that mothers of children with hypospadias may have higher level of polybrominated diphenyl ethers (PBDEs) exposures during pregnancy. The prevalence of hypospadias has increased in the past few decades worldwide and this study could partially explain the association between the global use of PBDEs for flame retardant and hypospadias. However, we still have some comments for the study methods and other potential factors for future analysis.

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