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January 7, 2019

Carelessness About Surfactant Dose—A Cultural Problem, a Legal Issue, or an Open Research Question?

Author Affiliations
  • 1Division of Pediatrics, Transportation, and Neonatal Critical Care, Hôpital Antoine Béclère, South Paris University Hospitals, Assistance Publique–Hôpitaux de Paris, Paris, France
  • 2Physiopathology and Therapeutic Innovation Unit, South Paris–Saclay University, Paris, France
JAMA Pediatr. Published online January 7, 2019. doi:10.1001/jamapediatrics.2018.4296

“Everything is poisonous, nothing is poisonous: it is all a matter of dose,” Claude Bernard stated, echoing Paracelsus’ long-ago dictum, often repeated in paraphrase as “Sola dosis facit venenum [only dose makes the poison].” Since then, finding the right dose for a drug has become one of the cornerstones of pharmaceutical research, and it currently represents the main purpose of phase I and phase II clinical trials. Modern research attempts to find the right drug at the right dose to be given at the right moment to the right patient with a particular disorder.

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