Acetaminophen, approved by the US Food and Drug Administration in 1951, is the most frequently used medication in children in the United States.1,2 In outpatient settings, up to 14% of children are treated with acetaminophen for pain and fever in any given week,1 while among hospitalized children, approximately 40% receive acetaminophen.2 The medication is available in multiple formulations, including a rectal suppository for patients unable to take medications by mouth and, most recently, an intravenous formulation, approved by the US Food and Drug Administration in November 2011.
Bourgeois FT, Graham DA, Kesselheim AS, Randolph AG. Cost Implications of Escalating Intravenous Acetaminophen Use in Children. JAMA Pediatr. Published online March 11, 2019173(5):489–491. doi:10.1001/jamapediatrics.2019.0101
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