To the Editor We read with great interest the article by Schrempft et al.1 The authors compared the differences in the level of correlations between monozygotic and dizygotic twins in home environments that were designated high risk or low risk for obesity. The environmental risk for obesity was evaluated using a questionnaire (Home Environment Interview) designed for the study (validation status unclear). Based on greater concordance between monozygotic twins compared with dizygotic twins in the designated obesogenic home environments, they concluded that obesity-related genes are more strongly associated with body mass index in these higher-risk environments. Interestingly, the authors also observed that the parents of children in lower-risk homes were significantly more likely to have professional occupations and the mothers to have tertiary education. We would be interested to know if these differences in parental status and education can explain the apparent differences in genetic risk for obesity,2 without the need for the questionnaire.
Jaffer S, Goel D, Poulton A. Additional Data to Explain Childhood Obesity. JAMA Pediatr. 2019;173(6):604–605. doi:10.1001/jamapediatrics.2019.0373
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