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May 28, 2019

Aspirin for the Prevention of Preeclampsia and Potential Consequences for Fetal Brain Development

Author Affiliations
  • 1First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
JAMA Pediatr. 2019;173(7):619-620. doi:10.1001/jamapediatrics.2019.1260

Preeclampsia is a major cause of morbidity and mortality for both mother and fetus. With respect to neurodevelopment, preeclampsia has been associated with autism spectrum disorders and developmental delay.1 Currently, professional bodies such as the American College of Obstetricians and Gynecologists (ACOG) in the United States and the National Institute for Health and Care Excellence (NICE) in the United Kingdom suggest the prophylactic administration of aspirin to pregnant women considered at high risk for preeclampsia based on maternal characteristics and medical history to reduce preeclampsia and improve both maternal and neonatal outcomes. Nevertheless, relevant studies on the prevention of preeclampsia have produced conflicting results.

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