Target trough concentrations for vancomycin hydrochloride therapy in infants younger than 90 days are poorly defined. In adults, the pharmacodynamic target for Staphylococcus aureus correlates with the ratio of the area under the concentration-time curve over a 24-hour period (AUC24) to the minimum inhibitory concentration (MIC) of the bacteria exceeding 400 (ie, AUC24/MIC>400).1,2 There are no widely available AUC calculators that we know of for use in infants younger than 90 days to enable clinicians to determine the AUC24 at steady state (approximately 48 hours) based on a trough concentration. We developed a population-based pharmacokinetic model to determine the association between serum trough vancomycin concentrations and AUC24.
Gwee A, Cranswick N, McMullan B, et al. Defining Target Vancomycin Trough Concentrations for Treating Staphylococcus aureus Infection in Infants Aged 0 to 90 Days. JAMA Pediatr. Published online June 10, 2019. doi:10.1001/jamapediatrics.2019.1488
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