To the Editor We read with interest the article by Perrett et al1 published in JAMA Pediatrics, which used interrupted time-series analysis to study the association of rotavirus (RV) vaccination with incident type 1 diabetes (T1D) in Australia. We believe that given the data presented, the decline in T1D incidence after vaccine introduction is not consistent with the hypothesis that RV vaccine may be protective against T1D development. Rather, the abrupt decrease in incidence around the time of RV vaccine introduction suggests that an alternative cause should be sought.
Vajravelu ME, Tamaroff J, Shults J. Role of Rotavirus Vaccination in Decline in Incidence of Type 1 Diabetes. JAMA Pediatr. Published online July 15, 2019173(9):893. doi:10.1001/jamapediatrics.2019.2457
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