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Comment & Response
July 15, 2019

Role of Rotavirus Vaccination in Decline in Incidence of Type 1 Diabetes

Author Affiliations
  • 1Division of Endocrinology and Diabetes, The Children’s Hospital of Philadelphia, Philadelphia
  • 2Perelman School of Medicine, University of Pennsylvania, Philadelphia
  • 3Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia
JAMA Pediatr. 2019;173(9):893. doi:10.1001/jamapediatrics.2019.2457

To the Editor We read with interest the article by Perrett et al1 published in JAMA Pediatrics, which used interrupted time-series analysis to study the association of rotavirus (RV) vaccination with incident type 1 diabetes (T1D) in Australia. We believe that given the data presented, the decline in T1D incidence after vaccine introduction is not consistent with the hypothesis that RV vaccine may be protective against T1D development. Rather, the abrupt decrease in incidence around the time of RV vaccine introduction suggests that an alternative cause should be sought.