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Comment & Response
July 15, 2019

Coding Error in Study of Rotavirus Vaccination and Type 1 Diabetes in Children

Author Affiliations
  • 1Murdoch Children’s Research Institute, Royal Children’s Hospital, School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia
  • 2Clinical Epidemiology and Biostatistics Unit, Murdoch Children’s Research Institute, Parkville, Victoria, Australia
  • 3Walter and Eliza Hall Institute for Medical Research, University of Melbourne, Melbourne, Victoria, Australia
JAMA Pediatr. 2019;173(9):894-895. doi:10.1001/jamapediatrics.2019.2463

To the Editor We write to report a coding error that affected the reported type 1 diabetes (T1D) rates but not the overall findings in our Research Letter titled, “Association of Rotavirus Vaccination With the Incidence of Type 1 Diabetes in Children,”1 published online January 22, 2019, and in the March 2019 issue of JAMA Pediatrics. An incorrect code was used to identify total cases of T1D (“all_males” instead of “all_children”), which reduced the reported observed average rates of T1D per 100 000 children by approximately half. Our study used an interrupted time-series analysis to assess the incidence of newly diagnosed T1D in Australian school children in the 8 years before compared with the 8 years after the May 2007 introduction of routine oral rotavirus vaccination for infants 6 weeks and older. We determined the observed and modeled rates of new-onset T1D between 2000 and 2015, with population numbers for children aged 0 to 4 years, 5 to 9 years, and 10 to 14 years. We reported a decrease in incidence rates of T1D in children aged 0 to 4 years in the period following the introduction of rotavirus vaccination.