In Reply We thank Rosenbauer et al and Vajravelu et al for their comments on our Research Letter.1 Rosenbauer et al requested more details of the statistical methods. We used an interrupted time-series analysis (ITS)2 on the incidence of newly diagnosed type 1 diabetes (T1D) in children aged 8 years before and after the May 2007 introduction of routine infant oral rotavirus (RV) vaccination. Counts of new T1D cases by age were modeled as Poisson random variables. Publicly available population data for each age group and sex combination in each year were included as an offset in the model, and inference was on the relative change in incidence rates averaged over the preperiod and postperiod.
Perrett KP, Jachno K, Nolan TM. Role of Rotavirus Vaccination in Decline in Incidence of Type 1 Diabetes—Reply. JAMA Pediatr. Published online July 15, 2019173(9):895. doi:10.1001/jamapediatrics.2019.2460
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