In Reply We thank Karina and Zhou for their interest in our study.1 We followed up infants who were exposed to gestational diabetes in utero and showed that high infant soothability was associated with a 2-fold higher odds of subsequent child obesity while accounting for numerous potential confounders that were evaluated during prenatal and early postnatal periods. However, Karina and Zhou challenge the validity of the parent-reported Infant Behavior Questionnaire (IBQ)2 methods, stating “the subjective nature of infant temperament makes it difficult for it to be a reliable measure,” and concluding that our findings are not valid and resulted from residual confounding by maternal depression among other covariates.
Faith MS, Hittner JB, Gunderson EP. Links Between Childhood Obesity, Gestational Diabetes, and Infant Temperament—Reply. JAMA Pediatr. 2019;173(10):1000. doi:10.1001/jamapediatrics.2019.2746
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