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Research Letter
September 3, 2019

Association of Blood Marker of Inflammation in Late Adolescence With Premature Mortality

Author Affiliations
  • 1Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York
  • 2Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts
  • 3Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden
  • 4Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts
  • 5Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, Massachusetts
  • 6Center of Public Health Sciences, Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
  • 7Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
  • 8Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
  • 9Department of Epidemiology and Public Health, University College London, London, United Kingdom
  • 10Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
JAMA Pediatr. Published online September 3, 2019. doi:10.1001/jamapediatrics.2019.2835

Inflammation is implicated in various diseases, including cancer and cardiovascular disease (CVD). Despite increasing interest in the role of childhood and adolescent exposures in later-life disease, little is known about the long-term implications of early inflammation. Here, we evaluate the association of inflammation in late adolescence as measured by erythrocyte sedimentation rate (ESR) with cause-specific mortality among ostensibly healthy men assessed for conscription in the Swedish military.