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September 30, 2019

Invasive Pneumococcal Disease—Not Evenly Shared by All Children

Author Affiliations
  • 1Division of Pediatric Infectious Diseases, Department of Pediatrics, Boston Medical Center, Boston, Massachusetts
  • 2Department of Pediatrics, Boston University School of Medicine, Boston, Massachusetts
  • 3Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia
  • 4Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia
  • 5Center for Childhood Infections and Vaccines, Atlanta, Georgia
JAMA Pediatr. 2019;173(11):1023-1024. doi:10.1001/jamapediatrics.2019.3185

It has been almost 20 years since the first conjugated pneumococcal vaccine (PCV) was introduced into childhood immunization schedules in the United States. Dramatic reductions in invasive pneumococcal disease (IPD) burden have been reported not only among children targeted for vaccination but also among unvaccinated children and adults in all settings following widespread use of the vaccine. These reductions are associated with reductions in nasopharyngeal colonization by vaccine serotypes and reduced transmission from vaccinated children.1 However, disease is not evenly distributed, and children with underlying clinical conditions are disproportionately represented among cases of IPD, especially among children older than 5 years.

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