To the Editor In their meta-analysis,1 Ching et al estimated the safety and maximum-dose titration of methylphenidate for attention-deficit/hyperactivity disorder (ADHD). This article reports on 11 randomized clinical trials including 1304 participants treated with methylphenidate and 887 control individuals and 38 cohort studies including 5524 participants. The evidence from this meta-analysis showed that a range of maximum doses for methylphenidate was recommended in different clinical studies and no discernable scientific justification for any particular dose was offered. This meta-analysis is an advanced study to summarize and compare findings from clinical studies. However, there might be some limitations in this study.
Cui Z, Liu H. Effective Stimulant Dosing in Attention-Deficit/Hyperactivity Disorder. JAMA Pediatr. 2019;173(12):1211. doi:10.1001/jamapediatrics.2019.3817
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